Effect of Ozone on Oxygen Transport and Pro-Oxidant- Antioxidant Balance of Red Blood Cell Suspension

Introduction: Ozone affects blood oxygen transport and the pro-oxidant-antioxidant balance. However, role of formed elements gas transmitters in these processes still remains unclear. The aim present study was to investigate effect ozone on balance a red cell suspension. Methods: suspension incubated with at concentration 6 mg/l substances affecting synthesis (nitroglycerin, sodium hydrosulfide). Parameters were determined. Results: found which manifested an increase partial pressure degree oxygenation. index hemoglobin –oxygen affinity p50 actual raised shift oxyhemoglobin dissociation curve rightwards noticed. addition transmitter donor, nitric oxide, enhanced this parameters erythrocyte Conclusion: We that induced change oxygen-binding properties is mechanism action above adaptive body realized directly level erythrocytes.